Product Name: Kudzu Root extract
Appearance: Light yellow powder
Specification: Isoflavones>40%
Test Method: HPLC
Packing: 25Kg/drum


Pueraria Root P.E.
Latin name: Pueraria lobata
Chinese Pin-Yin name: Ge Gen
Family: Legurninosae
Genus: Pueraria
Part used: Root
Description:
Pueraria Root is a perennial, trailing or climbing vine of the Legume family. The first written mention of the plant as a medicine is in the ancient herbal text of Shen Nong (circa A.D. 100) in China. In Traditional Chinese Medicine, Pueraria Root is used in prescriptions for the treatment of stomach discomforts, thirst, headache, and stiff neck with pain due to high blood pressure. It is also used in modern Chinese medicine as a treatment for angina pectoris, allergies, migraines, and diarrhea..
Function:
Pueraria Root is rich in isoflavones, such as puerarin,daidzin and daidzein. Isoflavones of Pueraria Root show very similar function to estrogen, thus they can be used to treat the syndromes of menopausal women. Pueraria Root Extract is also active in boosting blood volume of the coronary artery vessels, promoting the production of body fluid to quench thirst, improving the eruption of measles to allaying fever and stopping diarrhea. It relieves tension in the muscles and promotes blood circulation. This herb is traditionally used to treat fever, colds, migranes, and diarrhea.

Like other flavonoid substances, the constituents in kudzu root are associated with improved microcirculation and blood flow through the coronary arteries. A widely publicized 1993 animal study showed that both daidzin and daidzein inhibit the desire for alcohol. The authors concluded the Pueraria Root extract may in fact be useful for reducing the urge for alcohol and as treatment for alcoholism, Although this has not yet been proven in controlled clinical studies with humans.
Application:
Pueraria extract has been introduced just recently. With modern extraction technology, the extract from dried roots is standardized and prepared in the form of powder and solution.
1、Estrogenic Effects
To evaluate the estrogenic effects of Pueraria extract, a clinical trial in five female volunteers with menopausal symptoms showed that it clearly improved the signs and symptoms related to menopause such as, hot flushes, frustration, sleep disorder, skin dryness, high blood cholesterol, oligomenorrhoea and amenorrhoea; with no change in the blood cells, liver and kidney functions.
2. As Cosmetics
The extract solution is used in cosmetic industry such as preparations of breast cream, eye gel, and skin moisturizer. When Pueraria is taken as a dietary supplement, its phytoestrogen constituents will naturally alleviate symptoms occurring as a result of the aging process and a deficiency in estrogen level, e.g., sagging breasts, wrinkled skin, marrow loss, gray hair, and etc. These aging signs and symptoms will, to a certain extent, be reversed.
3. Lowered Risks of Cardiovascular-related Diseases
There are evidences that phytoestrogen consumption contributes to lower risks of cardiovascular related
diseases. In a study, it was proven that phytoestrogens in Pueraria can decrease the level of LDL cholesterol and increase the level of HDL cholesterol in the blood, therefore reducing the risk of cardiovascular diseases. Moreover, it was reported that subjects who consumed Pueraria extract at least three times daily had a decrease in the levels of total cholesterol, LDL cholesterol and triglyceride. Moreover, in toxicity study in rats, a very significant reduction of blood cholesterol levels in all groups of Pueraria -treated rats was also observed.
4、Headache and Migraine
Symptomatic improvement was achieved in 35 of 42 migraine cases. In hypertensive patients, it improved the cerebral blood flow, lowered the vascular resistance, and shortened the influx time in about 50% of the cases .
5、Hypertension
The total Pueraria isoflavones (100 mg daily in two doses) was given for a course of 2-8 weeks to 222 cases of hypertension with pain and stiffness of the neck. 78-90% of the cases reported relief of neck symptoms. In 90% of the cases remedial effects appeared after one week of administration, persisting for one to two weeks. In some patients there were no relapses during a period of 3 to 9 months after discontinuation of therapy.
6、Coronary Disease and Angina Pectoris
191 cases of coronary disease and angina pectoris were treated with Ge-Gen tablet (each tablet contains 10 mg of total isoflavones), 3-4 tablets three times a day. This treatment was effective in relief of anginal pain and in improving ECG . Another group of 110 cases of coronary disease were treated with a compound of Puerarin extract, 90% of them had relief of anginal pain and 43% had marked improvement.
Animal tests:
1、In 1991, scientists at Shin-Yang University in China began testing an herbal compound derived from Kudzu using rats that had been injected with alcohol. They found that it improved the rats' motor coordination, or made them less "drunk." A widely publicized 1993 animal study showed that both daidzin and daidzein inhibit the desire for alcohol.3 The authors concluded the root extract may in fact be useful for reducing the urge for alcohol and as treatment for alcoholism.
2、Sixty-four lambs in North Sumatra were used in a factorial experiment comprising two systems of management (grazing and stall-feeding), four levels of legume supplementation (0, 250, 500 and 1,000 g/d Pueraria javanica) and two anthelmintic treatments (none and albendazole every four weeks). Pueraria javanica supplement to lambs reduced intestinal worm egg count and no significant effect on mortality or growth rate.
3、A medicinal plant, Pueraria tuberosa D.C. has been thoroughly investigated for its contraceptive potency in various animals viz. rats, mice and hamsters. The activity has been further confirmed with respect to its habitat and seasonal variations. The potent fractions have been studied for their biological properties so as to elucidate its exact hormonal status. The observations suggest that tubers of P. tuberosa D.C. possess significant antifertility activity.
4. The effect of extracts of Pueraria tuberosa DC has been studied on the oestrous cycle of adult rats. It is found
that when petroleum ether and benzene extracts are given orally to normal cyclic rats, within 3-4 days the diestrus phase is transformed into a prolonged cornified stage, which persisted till the last day of treatment indicating thereby the estrogenic nature of the extracts. The administration of crude powder and ethanolic extract also induced cornification but after the 13th day, the cornified stage changed to the diestrus stage which continued till the last day of treatment. This type of change is thought to be due to the multiple hormonal properties of the crude powder and ethanolic extract.
5、Inhibition of Platelet Aggregation：ADP-induced rat platelet aggregation was inhibited to different extents by 0.25, 0.5, and 1.0 mg/ml of Puerarin in vitro, and also intravenous injection. At doses of 0.5 ? 3.0mg/ml, Puerarin also inhibited (in vitro) aggregation of rabbit and sheep platelets, and those of normal subjects induced by ADP or serotonin. It can also inhibit secretion of serotonin from platelets [7]. This effect is favorable to the prevention and treatment of angina pectoris and myocardial infarction.
6、Hypotensive Effects：Pueraria?s total flavones can causes hypertensive dogs and normotensive anesthetized dogs to lower their blood pressure. In hypertensive dogs, the pressure response to norepinephrine and the hypotensive effect of acetylcholine could be attenuated by the ethanol extract of Gegen . It has a direct vasodilatory action, which decreases the peripheral vascular resistance . It can also decrease the blood catecholamine level and vascular reactivity . This may be the reason why it can be effectively used for treating migraine headaches.


Safety:
Based on its extensive food use, Pueraria is believed to be reasonably safe. Pueraria should not be used by those with cold in the stomach and excessive sweating. There have been no reports of Pueraria toxicity in human.
Dosage:
The recommended dosage of standardized kudzu root extract is 6-12 tablets/day (10 mg isoflavones/tablet )to relieve menopausal syndromes, migraine and hypertension. This would equate to 60-120 mg two to three times per day.
Chemistry:
This product is composed of Isoflavones such as Puerarin、Daidaien and Daidzin.